Alidzhanova Kh G, Tvorogova M G, Rozhkova T A, Balakhonova T V, Vorob'eva L P, Masenko V P, Kukharchuk V V
Ter Arkh. 1998;70(1):19-23.
Study of the incidence of hyperlipidemias and coronary atherosclerosis risk factors.
A clinical and biochemical study of 35 children (25 men and 10 women aged 6 to 27 years) from 30 families of probands with primary hyperlipoproteinemias (HLP) was carried out. Use of modified risk factors (RF) in the examined group permitted the detection of hypodynamia in 25 subjects, obesity in 4, alcohol abuse and tobacco smoking in 1, and disorders of lipid metabolism in 31 (88%) cases.
Hypercholesterolemia was detected in 26 examinees, combined HLP in 1, hypoalphacholesterolemia in 3, and type V hyperlipoproteinemia in 1 case. The level of lipoprotein (a) was increased and positively correlated with xanthomatosis and the age of examinees. The level of basal immunoreactive insulin was within the normal range of values. Analysis of the relationship of this parameter and other coronary atherosclerosis RF revealed a correlation of the level of immunoreactive insulin and content of blood low-density lipoprotein cholesterol. In only 2 of the 30 examined families of probands with primary HLP there were no disorders of lipid metabolism and other modified RF.
Children, adolescents, and young people from families with primary HLP represent a risk group; they are to be regularly examined in order to prevent coronary disease and atherosclerosis and to detect and treat it in time.
研究高脂血症的发病率及冠状动脉粥样硬化危险因素。
对来自30个原发性高脂蛋白血症（HLP）先证者家庭的35名儿童（25名男性和10名女性，年龄6至27岁）进行了临床和生化研究。在受检组中使用改良的危险因素（RF），发现25名受试者有运动不足，4名有肥胖，1名有酗酒和吸烟情况，31例（88%）有脂质代谢紊乱。
26名受检者检测出高胆固醇血症，1名合并HLP，3名低α胆固醇血症，1例V型高脂蛋白血症。脂蛋白（a）水平升高，与黄瘤病和受检者年龄呈正相关。基础免疫反应性胰岛素水平在正常范围内。分析该参数与其他冠状动脉粥样硬化RF的关系，发现免疫反应性胰岛素水平与血液低密度脂蛋白胆固醇含量相关。在30个原发性HLP先证者受检家庭中，只有2个家庭没有脂质代谢紊乱和其他改良RF。
来自原发性HLP家庭的儿童、青少年和年轻人属于危险人群；应对他们进行定期检查，以预防冠心病和动脉粥样硬化，并及时发现和治疗。
