Activation of Ca(2+)-sensitive cytosolic phospholipase A2 (cPLA2) in human platelets. - Suppr | 超能文献

Activation of Ca(2+)-sensitive cytosolic phospholipase A2 (cPLA2) in human platelets.

作者信息

Kramer R M, Roberts E F, Jakubowski J A

机构信息

Lilly Research Laboratories, Indianapolis, IN 46285, USA.

出版信息

Adv Exp Med Biol. 1997;400A:19-24. doi: 10.1007/978-1-4615-5325-0_3.

DOI:10.1007/978-1-4615-5325-0_3

Abstract

摘要

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Activation of Ca(2+)-sensitive cytosolic phospholipase A2 (cPLA2) in human platelets.

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p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2.p38丝裂原活化蛋白激酶在凝血酶刺激的血小板中使胞质型磷脂酶A2（cPLA2）磷酸化。有证据表明cPLA2动员花生四烯酸并不需要脯氨酸定向磷酸化。

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Translocation and phosphorylation of cytosolic phospholipase A2 in activated platelets.活化血小板中胞质型磷脂酶A2的易位与磷酸化

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Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A2-alpha.多氯联苯通过激活IVA组胞质磷脂酶A2-α，以一种对他莫昔芬敏感的方式诱导人血小板中花生四烯酸的释放。

Biochem Pharmacol. 2005 Dec 19;71(1-2):144-55. doi: 10.1016/j.bcp.2005.10.014. Epub 2005 Nov 14.

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Stimulation of cytosolic phospholipase A2-catalyzed arachidonic acid liberation by low dose tert-butyl hydroperoxide without an influence on the enzyme activity in rabbit platelets.低剂量叔丁基过氧化氢刺激兔血小板中胞质磷脂酶A2催化的花生四烯酸释放，且对该酶活性无影响。

Biochem Mol Biol Int. 1997 Nov;43(4):799-806. doi: 10.1080/15216549700204611.

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Thrombin-induced phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in human platelets.凝血酶诱导人血小板中钙敏感的胞质磷脂酶A2的磷酸化和激活。

J Biol Chem. 1993 Dec 15;268(35):26796-804.

7

Increased cytosolic phospholipase A2 activity is not accompanied by arachidonic acid liberation in U46619-stimulated rabbit platelets.在U46619刺激的兔血小板中，胞质磷脂酶A2活性增加并未伴随花生四烯酸的释放。

Biochem Mol Biol Int. 1995 Feb;35(2):275-81.

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Acceleration by ceramide of calcium-dependent translocation of phospholipase A2 from cytosol to membranes in platelets.神经酰胺对血小板中磷脂酶A2钙依赖性从胞质溶胶向膜转位的促进作用。

Arch Biochem Biophys. 2000 Oct 15;382(2):296-302. doi: 10.1006/abbi.2000.2028.

9

Ca(2+)-sensitive cytosolic phospholipase A2 (cPLA2) in human platelets.人血小板中对钙离子敏感的胞质型磷脂酶A2（cPLA2）

J Lipid Mediat. 1993 Mar-Apr;6(1-3):209-16.

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Secretory phospholipase A2 is not required for arachidonic acid liberation during platelet activation.在血小板激活过程中，花生四烯酸的释放并不需要分泌型磷脂酶A2。

Eur J Biochem. 1993 Aug 15;216(1):169-75. doi: 10.1111/j.1432-1033.1993.tb18129.x.

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