利用交感胆碱能系统对可乐定作用部位的研究。

Studies on the site of action of clonidine utilizing a sympathetic-cholinergic system.

作者信息

Koss M C

出版信息

Eur J Pharmacol. 1976 Jun;37(2):381-4. doi: 10.1016/0014-2999(76)90046-7.

Abstract

Clonidine (30 mug/kg, i.v.) reduced centrally evoked electrodermal responses (EDR) following stimulation of reactive loci in the hypothalamus and medulla. The responses were most depressed following low frequency stimulation. Similar results were observed on the EDR evoked by stimulation of the cervical cord in the spinal cat. Little effect was seen following peripheral nerve stimulation. These results demonstrate that clonidine depresses the reactivity of this sympathetic-cholinergic system at all central levels including the cervical cord.

摘要

可乐定（30微克/千克，静脉注射）可降低下丘脑和延髓中反应位点受到刺激后中枢诱发的皮肤电反应（EDR）。在低频刺激后，这些反应受到的抑制最为明显。在脊髓猫中，刺激颈髓诱发的EDR也观察到了类似结果。外周神经刺激后几乎没有影响。这些结果表明，可乐定可抑制包括颈髓在内的所有中枢水平的这种交感 - 胆碱能系统的反应性。