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哈里斯-本尼迪克特人体基础代谢研究:历史与局限性

The Harris-Benedict studies of human basal metabolism: history and limitations.

作者信息

Frankenfield D C, Muth E R, Rowe W A

机构信息

Division of Gastroenterology, The Pennsylvania State University Milton S. Hershey Medical Center, Hershey 17033, USA.

出版信息

J Am Diet Assoc. 1998 Apr;98(4):439-45. doi: 10.1016/S0002-8223(98)00100-X.

Abstract

In the early part of the 20th century, numerous studies of human basal metabolism were conducted at the Nutrition Laboratory of the Carnegie Institution of Washington in Boston, Mass, under the direction of Francis G. Benedict. Prediction equations for basal energy expenditure (BEE) were developed from these studies. The expressed purpose of these equations was to establish normal standards to serve as a benchmark for comparison with BEE of persons with various disease states such as diabetes, thyroid, and other febrile diseases. The Harris-Benedict equations remain the most common method for calculating BEE for clinical and research purposes. The widespread use of the equations and the relative inaccessibility of the original work highlights the importance of reviewing the data from which the standards were developed. A review of the data reveals that the methods and conclusions of Harris and Benedict appear valid and reasonable, albeit not error free. All of the variables used in the equations have sound physiologic basis for use in predicting BEE. Supplemental data from the Nutrition Laboratory indicates that the original equations can be applied over a wide range of age and body types. The commonly held assumption that the Harris-Benedict equations overestimate BEE in obese persons may not be true for persons who are moderately obese.

摘要

20世纪初,在马萨诸塞州波士顿的华盛顿卡内基研究所营养实验室,在弗朗西斯·G·本尼迪克特的指导下,开展了大量关于人体基础代谢的研究。基于这些研究得出了基础能量消耗(BEE)的预测方程。这些方程的明确目的是建立正常标准,作为与患有各种疾病(如糖尿病、甲状腺疾病和其他发热性疾病)的人的BEE进行比较的基准。哈里斯-本尼迪克特方程仍然是临床和研究中计算BEE最常用的方法。这些方程的广泛使用以及原始研究相对难以获取,凸显了回顾制定这些标准所依据的数据的重要性。对这些数据的回顾表明,哈里斯和本尼迪克特的方法和结论虽然并非完全没有错误,但似乎是合理有效的。方程中使用的所有变量在预测BEE方面都有合理的生理基础。营养实验室的补充数据表明,原始方程可适用于广泛的年龄和体型范围。普遍认为哈里斯-本尼迪克特方程高估肥胖者BEE的观点,对于中度肥胖者可能并不成立。

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