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[心搏停止性癫痫发作]。

[Asystolic seizures].

作者信息

Kowalik A, Bauer J, Elger C E

机构信息

Klinik für Epileptologie, Rheinische Friedrich-Wilhelms-Universität Bonn.

出版信息

Nervenarzt. 1998 Feb;69(2):151-7. doi: 10.1007/s001150050252.

Abstract

Epileptic seizures may alter autonomic functions. This is especially the case with complex focal seizures (of temporal lobe origin) and grand mal. Most frequently, such seizures cause ictal tachycardia, sometimes tachypnea, probably caused by the propagation of epileptic discharges to autonomic cerebral structures. Ictal bradycardia and asystole are rare phenomena. However, they may be life threatening. Their differentiation from primary cardiac arrest is possible by the use of ictal EEG and ECG registration. Postictal serum prolactin measurement does not differentiate syncope from seizure. However, a postictal increase of creatine kinase is only measured after epileptic seizures and not after syncope. Treatment of such epileptic seizures includes an optimization of anticonvulsant drug therapy and the implantation of a cardiac demand stimulator. There is growing evidence that ictal asystole is a cofactor in sudden unexplained death in epileptic patients.

摘要

癫痫发作可能会改变自主神经功能。复杂局灶性发作(起源于颞叶)和全身性强直阵挛发作尤其如此。最常见的是,此类发作会导致发作期心动过速,有时也会导致呼吸急促,这可能是由于癫痫放电传播至自主神经脑结构所致。发作期心动过缓和心搏停止是罕见现象。然而,它们可能危及生命。通过发作期脑电图和心电图记录,可将其与原发性心脏骤停区分开来。发作后血清催乳素测量无法区分晕厥和癫痫发作。然而,仅在癫痫发作后而非晕厥后可测得发作后肌酸激酶升高。此类癫痫发作的治疗包括优化抗惊厥药物治疗以及植入心脏按需起搏器。越来越多的证据表明,发作期心搏停止是癫痫患者不明原因猝死的一个辅助因素。

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