α-生育酚状态对大鼠肝脏中α-生育酚转运蛋白表达及其信使核糖核酸水平的影响。
Effect of alpha-tocopherol status on alpha-tocopherol transfer protein expression and its messenger RNA level in rat liver.
作者信息
Kim H S, Arai H, Arita M, Sato Y, Ogihara T, Inoue K, Mino M, Tamai H
机构信息
Department of Pediatrics, Osaka Medical College, Takatsuki, Japan.
出版信息
Free Radic Res. 1998 Jan;28(1):87-92. doi: 10.3109/10715769809097879.
Studies were designed to explore the role of vitamin E nutritional status in regulating the synthesis of alpha-tocopherol transfer protein (alphaTTP) in rat liver. In vitamin E-replete rats, expression of this protein and its specific messenger RNA (mRNA) was decreased by about 300% compared with rats with normal vitamin E levels. In vitamin E-depleted rats, the alphaTTP-specific mRNA level increased to about 150% of that in the normal vitamin E group. However, protein expression remained constant. These findings indicate that the synthesis of alphaTTP can be regulated by the vitamin E nutritional status.
研究旨在探讨维生素E营养状况在调节大鼠肝脏中α-生育酚转运蛋白（alphaTTP）合成中的作用。在维生素E充足的大鼠中，与维生素E水平正常的大鼠相比，该蛋白及其特异性信使核糖核酸（mRNA）的表达降低了约300%。在维生素E缺乏的大鼠中，alphaTTP特异性mRNA水平增加至正常维生素E组的约150%。然而，蛋白质表达保持不变。这些发现表明，alphaTTP的合成可受维生素E营养状况的调节。
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