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人类唾液蛋白复合体（SPC）：一大组相关基因。

The human salivary protein complex (SPC): a large block of related genes.

作者信息

Goodman P A, Yu P L, Azen E A, Karn R C

机构信息

Department of Medical Genetics, Indiana University School of Medicine, Indianapolis 46223, USA.

出版信息

Am J Hum Genet. 1985 Jul;37(4):785-97.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1684626/

Abstract

We have shown that genes for at least six human parotid proteins, parotid acidic protein (Pa), proline-rich protein (Pr), double-banded protein (Db), glycoprotein (Gl), parotid middle-band protein (Pm), and parotid-size variant (Ps) are linked. We have designated this complex of genes as the salivary protein complex (SPC). Several of the genes in this complex show marked associations that are most likely the result of linkage disequilibrium. It seems likely that the SPC arose through the process of gene duplication. This hypothesis is supported by the results of our present study that demonstrate the biochemical similarity of the protein products of several SPC genes. The amino acid compositions of the major SPC proteins are compared, including several (Ps 1 and 2, and Db) that have not been published. All of these proteins are quite similar and consist to a large extent of the amino acids, proline, glycine, and gix (glutamine and/or glutamic acid).

摘要

我们已经证明，至少六种人类腮腺蛋白的基因，即腮腺酸性蛋白（Pa）、富含脯氨酸蛋白（Pr）、双条带蛋白（Db）、糖蛋白（Gl）、腮腺中带蛋白（Pm）和腮腺大小变体（Ps）是连锁的。我们将这个基因复合体命名为唾液蛋白复合体（SPC）。该复合体中的几个基因显示出明显的关联，这很可能是连锁不平衡的结果。唾液蛋白复合体似乎是通过基因复制过程产生的。我们目前的研究结果支持了这一假设，这些结果证明了几个唾液蛋白复合体基因的蛋白质产物在生化上具有相似性。比较了主要唾液蛋白复合体蛋白的氨基酸组成，包括几种尚未发表的蛋白（Ps 1和2以及Db）。所有这些蛋白质都非常相似，并且在很大程度上由脯氨酸、甘氨酸和gix（谷氨酰胺和/或谷氨酸）组成。