Armstrong T D, Pulaski B A, Ostrand-Rosenberg S
Department of Biological Sciences, University of Maryland, Baltimore 21250, USA.
Cancer Immunol Immunother. 1998 Apr;46(2):70-4. doi: 10.1007/s002620050463.
Cell-based tumor vaccines have been developed on the basis of the hypothesis that tumor cells can be genetically modified to present antigen to T lymphocytes directly. Contrary to expectations, cross-priming is the predominant pathway for activation of tumor-specific CD8+ T cells, while direct presentation of antigen dominates activation of tumor-specific CD4+ T cells. These results pose interesting paradoxes for the generation of immune responses, and have definite implications for the development of anti-cancer vaccines.
基于肿瘤细胞可经基因改造直接向T淋巴细胞呈递抗原这一假说,已研发出细胞型肿瘤疫苗。与预期相反,交叉呈递是激活肿瘤特异性CD8+ T细胞的主要途径,而抗原的直接呈递则主导着肿瘤特异性CD4+ T细胞的激活。这些结果给免疫应答的产生带来了有趣的矛盾之处,并且对抗癌疫苗的研发具有明确的启示意义。