van Meerwijk J P, Bianchi T, Marguerat S, MacDonald H R
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.
J Immunol. 1998 Apr 15;160(8):3649-54.
During their development, immature CD4+ CD8+ thymocytes become committed to either the CD4 or CD8 lineage. Subsequent complete maturation of CD4+ and CD8+ cells requires a molecular match of the expressed coreceptor and the MHC specificity of the TCR. The final size of the mature CD4+ and CD8+ thymic compartments is therefore determined by a combination of lineage commitment and TCR-mediated selection. In humans and mice, the relative size of CD4+ and CD8+ peripheral T cell compartments shows marked genetic variability. We show here that genetic variations in thymic lineage commitment, rather than TCR-mediated selection processes, are responsible for the distinct CD4/CD8 ratios observed in common inbred mouse strains. Genetic variations in the regulation of lineage commitment open new ways to analyze this process and to identify the molecules involved.
在其发育过程中，未成熟的CD4+CD8+胸腺细胞会定向分化为CD4或CD8谱系。随后，CD4+和CD8+细胞的完全成熟需要所表达的共受体与TCR的MHC特异性在分子水平上相匹配。因此，成熟的CD4+和CD8+胸腺区室的最终大小由谱系定向和TCR介导的选择共同决定。在人类和小鼠中，CD4+和CD8+外周T细胞区室的相对大小表现出显著的遗传变异性。我们在此表明，胸腺谱系定向中的遗传变异，而非TCR介导的选择过程，是导致常见近交系小鼠品系中观察到不同CD4/CD8比率的原因。谱系定向调控中的遗传变异为分析这一过程及鉴定相关分子开辟了新途径。
