五天间歇性与七天持续性输注2-氯脱氧腺苷治疗毛细胞白血病。意大利毛细胞白血病研究小组的一项研究。
Five day intermittent vs seven day continuous 2-chlorodeoxyadenosine infusion for the treatment of hairy cell leukemia. A study by Italian Group for the Hairy Cell Leukemia.
作者信息
Damasio E E, Resegotti L, Masoudi B, Bruni R, Cerri R, Isaza A, Clavio M, Risso M, Rossi E, Spriano M, Truini M
机构信息
Divisione Ematologia 1, Ospedale San Martino, Genova.
出版信息
Recenti Prog Med. 1998 Feb;89(2):68-73.
The new purine-analogue 2-chlorodeoxyadenosine (2-CdA) has proved to induce an high CR rate and a long lasting disease free survival. In this study we compare the efficacy and toxicity of 2-CdA employed in two different schedules (A and B). Forty-one patients have been enrolled from 1994: 22 p. (group A) were treated with a single cycle of 2-CdA given as two hour i.v. infusion on 5 consecutive days (0.15 mg/kg/die); while 19 p. (group B) with continuous i.v. infusion for 7 consecutive days (0.10 mg/kg/die). Response criteria were those proposed by NCI. The Hairy Cell Index (HCI) was calculated using DBA44 MoAb. At three months, the responses in group A (19/22) were: 5 CR (26.3%), 6 GPR (31.5%), 5 PR and 3 NR.; in group B (17/19): 6 CR (35.3%), 3 GPR (17.6%), 4 PR and 4 NR. Overall response at six months was respectively 84.2% and 76.5%. At six months the responses were: in group A (18/22): 9 CR (50%), 4 GPR (22.2%), 3 PR, 2 NR; in group B (16/19): 4 CR (25%), 6 GPR (37.5%), 3 PR, 3 NR. Overall response at 6 months was respectively 88.8% (group A) and 81.2% (group B). The 5 day intermittent schedule appears efficient, well tolerated and suitable for out-patient treatment. DBA44 MoAb appears useful to better define the HCI and to distinguish CR from GPR.
新型嘌呤类似物2-氯脱氧腺苷（2-CdA）已被证明可诱导高完全缓解（CR）率和长期无病生存。在本研究中，我们比较了2-CdA按两种不同方案（A和B）使用时的疗效和毒性。1994年共纳入41例患者：22例（A组）接受单周期2-CdA治疗，连续5天静脉输注2小时（0.15mg/kg/天）；19例（B组）连续7天静脉输注（0.10mg/kg/天）。缓解标准采用美国国立癌症研究所（NCI）提出的标准。使用DBA44单克隆抗体（MoAb）计算毛细胞指数（HCI）。三个月时，A组（22例中的19例）的缓解情况为：5例完全缓解（26.3%），6例非常好的部分缓解（GPR，31.5%），5例部分缓解和3例未缓解；B组（19例中的17例）为：6例完全缓解（35.3%），3例非常好的部分缓解（17.6%），4例部分缓解和4例未缓解。六个月时的总体缓解率分别为84.2%和76.5%。六个月时的缓解情况为：A组（22例中的18例）：9例完全缓解（50%），4例非常好的部分缓解（22.2%），3例部分缓解，2例未缓解；B组（19例中的16例）：4例完全缓解（25%），6例非常好的部分缓解（37.5%），3例部分缓解，3例未缓解。六个月时的总体缓解率分别为88.8%（A组）和81.2%（B组）。5天间歇方案似乎有效、耐受性良好且适合门诊治疗。DBA44单克隆抗体似乎有助于更好地定义毛细胞指数，并区分完全缓解和非常好的部分缓解。
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