Quéreux C, Morice J, Level G, Ezes H, Wahl P
J Gynecol Obstet Biol Reprod (Paris). 1976 Jan-Feb;5(1):97-103.
A case of bismuth encephalopathy in a pregnant woman is reported. The neurological picture, characterized especially by myoclonic attacks, is no different from that found in the non-pregnant state. The principal observations are on three points: - the need to think of a toxic origin of convulsions in pregnancy, - the onset of threatened premature labour during repeated convulsive crises, - the passage of bismuth across the placenta : this has been proved by the levels found in the amniotic fluid (55 mcg per 1,000) and in the cord blood (320 mcg per 1,000). The child, who was normal at birth, developed a transient hypotonus which seemed attributable more to the treatment of the mother with Diazepam and pheno-barbitone than to her having taken bismuth during the pregnancy.
本文报告了一例孕妇铋中毒性脑病病例。其神经症状,尤其以肌阵挛发作为特征,与非孕期并无不同。主要观察有三点:一是孕期惊厥需考虑中毒性病因;二是反复惊厥发作期间出现先兆早产;三是铋可通过胎盘:羊水(每1000中有55微克)和脐血(每1000中有320微克)中的检测水平证实了这一点。该婴儿出生时正常,出现了短暂性肌张力减退,这似乎更多归因于母亲使用地西泮和苯巴比妥治疗,而非孕期服用铋剂。