足月儿和早产儿水通道蛋白-2的尿排泄情况。

Urinary excretion of aquaporin-2 in term and preterm infants.

作者信息

Tsukahara H, Hata I, Sekine K, Miura M, Hata K, Fujii Y, Mayumi M

机构信息

Department of Pediatrics, Fukui Medical School, Japan.

出版信息

Early Hum Dev. 1998 Apr 17;51(1):31-7. doi: 10.1016/s0378-3782(97)00072-8.

DOI:10.1016/s0378-3782(97)00072-8

PMID:9570029

Abstract

Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel of the renal collecting duct and is excreted in human urine. We measured the urinary excretion of AQP-2 by radioimmunoassay in 14 term and 12 preterm infants aged 1 month. Excretion of AQP-2 was low compared with adults, and correlated significantly with urine osmolality in preterm infants. Our results demonstrate that AQP-2 water channels are expressed in the renal collecting duct of both term and preterm infants.

摘要

水通道蛋白-2（AQP-2）是肾集合管中受血管加压素调节的水通道，可在人体尿液中排泄。我们通过放射免疫测定法测量了14名足月儿和12名1月龄早产儿尿液中AQP-2的排泄量。与成年人相比，AQP-2的排泄量较低，并且在早产儿中与尿渗透压显著相关。我们的结果表明，AQP-2水通道在足月儿和早产儿的肾集合管中均有表达。