羟基磷灰石填料颗粒与PEG/PBT共聚物基体之间具有化学键合的复合生物材料。

Composite biomaterials with chemical bonding between hydroxyapatite filler particles and PEG/PBT copolymer matrix.

作者信息

Liu Q, de Wijn J R, van Blitterswijk C A

机构信息

Biomaterials Research Group, Leiden University, Bilthoven, The Netherlands.

出版信息

J Biomed Mater Res. 1998 Jun 5;40(3):490-7. doi: 10.1002/(sici)1097-4636(19980605)40:3<490::aid-jbm20>3.0.co;2-m.

DOI:10.1002/(sici)1097-4636(19980605)40:3<490::aid-jbm20>3.0.co;2-m

PMID:9570082

Abstract

In an effort to make composites from hydroxyapatite and a PEG/PBT copolymer (Polyactive 70/30), chemical linkages were introduced between the filler particles and polymer matrix using hexamethylene diisocyanate as a coupling agent. Infrared spectra (IR) and thermal gravimetric analysis (TGA) confirmed the presence of Polyactive 70/30 on the surface of HA filler particles. The amount of chemically bound polymer was 4.7 wt.%, as determined by TGA. The mechanical properties of the composites, that is, tensile strength and Young's modulus, were improved significantly by the introduction of a chemical linkage between the filler particles and polymer matrix compared to control composites. This method provides an effective way to introduce chemical linkage between HA filler particles and a polymer matrix. By optimizing the grafting process, a further improvement of the mechanical properties in the composites can be expected.

摘要

为了用羟基磷灰石和聚乙二醇/聚对苯二甲酸丁二醇酯共聚物（Polyactive 70/30）制备复合材料，使用六亚甲基二异氰酸酯作为偶联剂在填料颗粒和聚合物基体之间引入化学键。红外光谱（IR）和热重分析（TGA）证实了在HA填料颗粒表面存在Polyactive 70/30。通过TGA测定，化学结合聚合物的量为4.7 wt.%。与对照复合材料相比，通过在填料颗粒和聚合物基体之间引入化学键，复合材料的机械性能，即拉伸强度和杨氏模量，得到了显著改善。该方法提供了一种在HA填料颗粒和聚合物基体之间引入化学键的有效途径。通过优化接枝过程，可以预期复合材料的机械性能会进一步提高。