Bingle C D
Rayne Institute, St Thomas's Hospital, London, U.K.
Int J Biochem Cell Biol. 1997 Dec;29(12):1471-3. doi: 10.1016/s1357-2725(97)00007-1.
Thyroid transcription factor-1 (TTF-1) is a recently identified member of the homeodomain transcription factor family, which plays a role in regulating genes expressed within the thyroid, lung and brain, including thyroglobulin, thyroid peroxidase, Clara cell secretory protein and the surfactant proteins. Additional studies, including gene targeting experiments, have clearly shown that expression of TTF-1 is essential for morphogenesis of the thyroid, lung and ventral forebrain, as TTF-1 knockout mice lack these organs. In the light of these studies it seems possible that mutations in TTF-1 may underlie certain abnormalities either of organogenesis of, or of cellular function within, these organ systems. A recent example of such a defect is the identification of a patient with thyroglobulin deficiency due to decreased TTF-1 expression.
甲状腺转录因子-1（TTF-1）是最近发现的同源结构域转录因子家族成员，它在调节甲状腺、肺和脑内表达的基因中发挥作用，这些基因包括甲状腺球蛋白、甲状腺过氧化物酶、克拉拉细胞分泌蛋白和表面活性物质蛋白。包括基因靶向实验在内的其他研究清楚地表明，TTF-1的表达对于甲状腺、肺和前脑腹侧的形态发生至关重要，因为TTF-1基因敲除小鼠缺乏这些器官。鉴于这些研究，TTF-1的突变似乎有可能是这些器官系统器官发生或细胞功能某些异常的基础。这种缺陷的一个最新例子是鉴定出一名由于TTF-1表达降低而患有甲状腺球蛋白缺乏症的患者。
