Rosas I, McCartney H A, Payne R W, Calderón C, Lacey J, Chapela R, Ruiz-Velazco S
Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Mexico DF.
Allergy. 1998 Apr;53(4):394-401. doi: 10.1111/j.1398-9995.1998.tb03911.x.
There have been several studies of the relationships between environmental factors, particularly air pollution, and attacks of asthma. Most of these studies have ignored the potential confounding effects of aeroallergens such as pollens and fungal spores. We report a statistical analysis of the relationships between emergency admissions for asthma to a hospital in Mexico City and daily average airborne concentrations of pollen, fungal spores, air pollutants (O3, NO2, SO2, and particulates) and weather factors. Asthma admissions had a seasonal pattern with more during the wet season (May-October) than the dry season (November-April). There were few statistical associations between asthma admissions and air pollutants for the three age groups studied (children under 15 years, adults, and seniors [adults over 59 years]) in either season. Grass pollen was associated with child and adult admissions for both the wet and dry seasons, and fungal spores were associated with child admissions during both the wet and dry seasons. The analysis was done with environmental data averaged over the day of admission and the 2 previous days. Our results suggest that aeroallergens may be statistically associated more strongly with asthma hospital admissions than air pollutants and may act as confounding factors in epidemiologic studies.
已有多项关于环境因素,尤其是空气污染与哮喘发作之间关系的研究。这些研究大多忽略了花粉和真菌孢子等空气过敏原的潜在混杂效应。我们报告了对墨西哥城一家医院哮喘急诊入院情况与花粉、真菌孢子、空气污染物(臭氧、二氧化氮、二氧化硫和颗粒物)的日平均空气浓度以及天气因素之间关系的统计分析。哮喘入院情况呈现季节性模式,雨季(5月至10月)的入院人数多于旱季(11月至4月)。在两个季节中,所研究的三个年龄组(15岁以下儿童、成年人和老年人[59岁以上成年人])的哮喘入院情况与空气污染物之间几乎没有统计学关联。草花粉在雨季和旱季均与儿童及成人入院情况相关,真菌孢子在雨季和旱季均与儿童入院情况相关。分析使用的是入院当天及前两日的环境数据平均值。我们的结果表明,在统计学上,空气过敏原与哮喘住院情况的关联可能比空气污染物更强,并且可能在流行病学研究中充当混杂因素。