Rollins E L, Fewell J E
Department of Physiology and Biophysics, University of Calgary, Health Sciences Centre, Alberta, Canada.
Am J Physiol. 1998 Apr;274(4):R1158-61. doi: 10.1152/ajpregu.1998.274.4.R1158.
In newborns and adults of a number of species including humans, exposure to acute hypoxemia produces a "regulated" decrease in core temperature, the mechanism of which is unknown. Considering that various cortical areas participate in autonomic regulation including thermoregulation, the present experiments were carried out to test the hypothesis that the cerebral cortex plays a role in modulating the regulated decrease in core temperature during acute hypoxemia. This hypothesis was tested by determining the core temperature response to acute hypoxemia in chronically instrumented adult Sprague-Dawley rats before and after cortical spreading depression (i.e., functional decortication) was produced by the local application of potassium chloride to the dura overlying the cerebral hemispheres. There was no effect of cortical spreading depression on baseline core temperature. Core temperature decreased during acute hypoxemia in a similar fashion when the cerebral cortex was intact as well as during functional decortication. Thus our data do not support the hypothesis that the cerebral cortex modulates the regulated decrease in core temperature that occurs in adult rats during acute hypoxemia.
在包括人类在内的多个物种的新生儿和成年个体中，暴露于急性低氧血症会导致核心体温出现“调节性”下降，其机制尚不清楚。鉴于包括体温调节在内的各种皮质区域参与自主调节，本实验旨在检验以下假设：在急性低氧血症期间，大脑皮层在调节核心体温的下降中发挥作用。通过测定成年慢性植入仪器的斯普拉格-道利大鼠在局部应用氯化钾于大脑半球上方硬脑膜产生皮质扩散性抑制（即功能性去皮质）前后对急性低氧血症的核心体温反应来检验这一假设。皮质扩散性抑制对基线核心体温没有影响。当大脑皮层完整时以及在功能性去皮质期间，急性低氧血症期间核心体温均以类似方式下降。因此，我们的数据不支持以下假设：大脑皮层调节成年大鼠在急性低氧血症期间出现的核心体温调节性下降。
