Odinot P T, Curfs J H, Meis J F, Melchers W J, Hoogkamp-Korstanje J A
Department of Medical Microbiology, University Hospital Nijmegen, The Netherlands.
Cytokine. 1998 Mar;10(3):206-12. doi: 10.1006/cyto.1997.0275.
The immune-response against infection with Yersinia enterocolitica was studied in a rat model which resembles yersiniosis in humans. Lewis, Fischer and Brown Norway rats were inoculated with Y. enterocolitica and the cytokine mRNA expression in spleen and Peyer's patches was determined. In Brown Norway rats the infection was mild and Yersinia enterocolitica was fully cleared. In these rats the highest anti-inflammatory cytokine expression was found probably resulting in a protective host defence against the infection. In both the Lewis and Fischer rats Y. enterocolitica persisted. The anti-inflammatory cytokine expression was less pronounced in these two rat strains. The authors conclude that progression of disease, persistence of infection and development of reactive arthritis, may be related to the local expression of specific cytokines.
在一种类似于人类耶尔森氏菌病的大鼠模型中，研究了针对小肠结肠炎耶尔森氏菌感染的免疫反应。给刘易斯、费舍尔和挪威棕色大鼠接种小肠结肠炎耶尔森氏菌，并测定脾脏和派尔集合淋巴结中的细胞因子mRNA表达。在挪威棕色大鼠中，感染较轻，小肠结肠炎耶尔森氏菌被完全清除。在这些大鼠中发现了最高的抗炎细胞因子表达，这可能导致宿主对感染的保护性防御。在刘易斯大鼠和费舍尔大鼠中，小肠结肠炎耶尔森氏菌都持续存在。在这两种大鼠品系中，抗炎细胞因子的表达不那么明显。作者得出结论，疾病的进展、感染的持续以及反应性关节炎的发展，可能与特定细胞因子的局部表达有关。
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