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[腹膜透析患者生存的预测因素]

[Factors predicting survival in patients on peritoneal dialysis].

作者信息

Leaños-Miranda A

机构信息

Hospital General de Zona No. 1-A Los venados, Instituto Mexicano del Seguro Social, México, D.F.

出版信息

Rev Invest Clin. 1997 Sep-Oct;49(5):355-60.

PMID:9580052
Abstract

OBJECTIVE

To determine the factors associated with survival in a cohort of 74 patients with end-stage renal disease (ESRD) undergoing chronic peritoneal dialysis (CPD).

SETTING

The study was carried out at a general hospital of the Instituto Mexicano del Seguro Social.

DESIGN

Analysis of a retrolective cohort under a nested case control design.

PATIENTS AND METHODS

The variables studied included age, gender, cause of ESRD (diabetic or non-diabetic), socioeconomic status, modality of CPD (intermittent vs continuous ambulatory peritoneal dialysis), catheters per patient, rate of peritonitis, levels of serum creatinine and albumin at the beginning of the CPD.

RESULTS

During a 75.1 years-patient follow up, there were 41 deaths (cases). The main cause of death was peritonitis. The cumulated survival of the 74 patients was 64%, 29% and 13% at 12, 24 and 33 months, respectively. Intermittent peritoneal dialysis, the rate of peritonitis and the level of basal serum albumin were associated with a decreased survival in a univariate analysis. Only a high rate of peritonitis was associated with an increase in mortality rate independent from other variables (p = 0.002).

CONCLUSIONS

The probability of survival in ESRD in our hospital was low in relation to other nephrology departments of Mexico and other countries. A high rate of peritonitis proved to be an important independent predictor of a lesser survival rate in patients under CPD in our institution.

摘要

目的

确定74例接受慢性腹膜透析(CPD)的终末期肾病(ESRD)患者队列中与生存相关的因素。

背景

该研究在墨西哥社会保障局综合医院开展。

设计

采用巢式病例对照设计对回顾性队列进行分析。

患者与方法

所研究的变量包括年龄、性别、ESRD病因(糖尿病性或非糖尿病性)、社会经济状况、CPD方式(间歇性与持续性非卧床腹膜透析)、每位患者的导管数量、腹膜炎发生率、CPD开始时的血清肌酐和白蛋白水平。

结果

在75.1年的患者随访期间,有41例死亡(病例)。主要死亡原因是腹膜炎。74例患者在12、24和33个月时的累积生存率分别为64%、29%和13%。单因素分析显示,间歇性腹膜透析、腹膜炎发生率和基础血清白蛋白水平与生存率降低相关。仅腹膜炎的高发生率与死亡率增加相关,且独立于其他变量(p = 0.002)。

结论

与墨西哥和其他国家的其他肾脏病科相比,我院ESRD患者的生存概率较低。腹膜炎的高发生率被证明是我院接受CPD治疗患者生存率较低的重要独立预测因素。

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