Walsh P N, Pareti F I, Corbett J J
N Engl J Med. 1976 Oct 14;295(16):854-8. doi: 10.1056/NEJM197610142951602.
To determine whether platelets play a part in the pathogenesis of transient cerebrovascular ischemia, we studied 22 patients with transient ischemia, 18 control patients and 38 normal subjects. Platelet aggregation and [14C]-serotonin release by ADP, epinephrine and collagen were normal in all patients, as were plasma coagulation assays, except for shortened partial thromboplastin times in the patients with transient ischemia. Platelet coagulant activities concerned with initiation and early stages of intrinsic coagulation were increased two to three times in 12 patients with transient ischemic attacks with normal serum lipids and normal in the 10 others with Type IV hyperlipoproteinemia. These results indicate an association between platelet coagulant hyperactivity and transient ischemic attacks in a group of patients with normal serum lipids.
为了确定血小板是否在短暂性脑血管缺血的发病机制中起作用，我们研究了22例短暂性缺血患者、18例对照患者和38名正常受试者。所有患者中，由ADP、肾上腺素和胶原诱导的血小板聚集及[14C] - 5 -羟色胺释放均正常，血浆凝血试验结果也正常，但短暂性缺血患者的部分凝血活酶时间缩短。在血清脂质正常的12例短暂性脑缺血发作患者中，与内源性凝血起始和早期阶段相关的血小板凝血活性增加了两到三倍，而在另外10例IV型高脂蛋白血症患者中则正常。这些结果表明，在一组血清脂质正常的患者中，血小板凝血活性亢进与短暂性脑缺血发作之间存在关联。
