平滑肌中收缩元件钙敏化的调节机制。

Regulatory mechanisms of calcium sensitization of contractile elements in smooth muscle.

作者信息

Hori M, Karaki H

机构信息

Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan.

出版信息

Life Sci. 1998;62(17-18):1629-33. doi: 10.1016/s0024-3205(98)00119-2.

DOI:10.1016/s0024-3205(98)00119-2

PMID:9585148

Abstract

It is evident that smooth muscle contraction is regulated not only by the Ca2+/calmodulin/myosin light chain kinase system but also by modulation of Ca2+ sensitivity. Changes in free calmodulin concentrations, myosin light chain phosphorylation elicited by rho/rho-kinase, regulation of myosin phosphatase activity and thin filament-linked mechanisms are the possible mechanisms for regulation of Ca2+ sensitivity.

摘要

显而易见，平滑肌收缩不仅受Ca2+/钙调蛋白/肌球蛋白轻链激酶系统调节，还受Ca2+敏感性调节。游离钙调蛋白浓度的变化、rho/rho激酶引发的肌球蛋白轻链磷酸化、肌球蛋白磷酸酶活性的调节以及细肌丝相关机制是调节Ca2+敏感性的可能机制。