由含异鸟嘌呤的寡核苷酸形成的平行链双链体和四重聚集体。
Parallel-stranded duplexes and quartet assemblies formed by oligonucleotides containing isoguanine.
作者信息
Seela F, Wei C, Melenewski A, Leonard P
机构信息
Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.
出版信息
Nucleic Acids Symp Ser. 1997(37):149-50.
Oligonucleotides with isoguanine-cytosine base pairs form duplexes with parallel chain orientation. This strong base pair dictates the strand polarity when additional dA-dT or N7Ad-dT pairs are present. The same is observed for the isocytosine-guanine pair. Quartet structures are built by the self-assembly of oligonucleotides containing short runs of isoguanine or 7-deazaisoguanine. New base pairs between isoguanine or guanine and 5-aza-7-deazaguanine are presented.
含有异鸟嘌呤-胞嘧啶碱基对的寡核苷酸形成具有平行链取向的双链体。当存在额外的dA-dT或N7Ad-dT碱基对时，这种强碱基对决定了链的极性。异胞嘧啶-鸟嘌呤对也观察到同样的情况。四重结构是由含有短链异鸟嘌呤或7-脱氮异鸟嘌呤的寡核苷酸自组装而成。本文还展示了异鸟嘌呤或鸟嘌呤与5-氮杂-7-脱氮鸟嘌呤之间的新碱基对。
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