Amaris J, Kardache M, Soyer P, Lalande F, Boudiaf M, Scherrer A, Rymer R
Service de Radiologie Viscérale, Hôpital Lariboisière, Paris.
Gastroenterol Clin Biol. 1997;21(11):888-92.
Localized macronodular tuberculosis of the liver is rare. Tuberculous involvement of the liver is usually a diffuse process. We report 3 cases in which clinical and imaging features suggested the diagnosis of macronodular hepatic tuberculoma which was pathologically confirmed by percutaneous biopsy. In the first case, abdominal CT-scan showed a noncalcified hypodense nodular lesion in segment IV of the liver with an enhancing peripheral rim. In the second case, ultrasound showed 4 homogenous hypoechoic hepatic nodules. In the third case, a nodule was incidentally identified in segment VII of the liver. The lesion was hypoechoic with ultrasound, hypodense without enhancement on CT-scan, and hyperintense on both T1- and T2-weighted MR imaging. After percutaneous biopsy, pathologic examination showed peripheral granulomous lesions in all patients with central caseous necrosis consistent with tuberculosis in two patients despite a negative for Zielh stain. Specific M. tuberculosis culture was positive in the first patient, negative in the second patient, and was not performed in the third patient. Appropriate treatment resulted in disappearance of hepatic lesions on follow-up imaging examinations. These 3 cases show that clinical and imaging features of hepatic tuberculoma are not specific and that percutaneous biopsy of lesions provides a definite diagnosis.
肝脏局限性大结节性结核较为罕见。肝脏结核受累通常是一个弥漫性过程。我们报告3例病例,其临床和影像学特征提示为大结节性肝结核瘤,经皮穿刺活检病理确诊。第一例中,腹部CT扫描显示肝脏IV段有一个无钙化的低密度结节性病变,周边有强化环。第二例中,超声显示4个均匀的低回声肝结节。第三例中,在肝脏VII段偶然发现一个结节。该病变超声表现为低回声,CT扫描无强化呈低密度,T1加权和T2加权磁共振成像均呈高信号。经皮穿刺活检后,病理检查显示所有患者均有周边肉芽肿性病变,2例患者中央有干酪样坏死,符合结核,尽管齐-尼氏染色阴性。第一例患者结核分枝杆菌培养阳性,第二例患者阴性,第三例患者未进行培养。适当治疗后,随访影像学检查显示肝脏病变消失。这3例病例表明,肝结核瘤的临床和影像学特征不具有特异性,对病变进行经皮穿刺活检可提供明确诊断。