Takesue F, Inutsuka S, Nagahama S, Kusumoto H, Korenaga D, Maekawa S, Ikeda T
Dept. of Surgery, Fukuoka Dental College.
Gan To Kagaku Ryoho. 1998 Apr;25 Suppl 3:464-8.
The present study was done to determine if carcinoembryonic antigen (CEA) concentration doubling time can predict the course of disease in patients with adenocarcinoma of the gastrointestinal tract and characterize tumor biology.
CEA doubling times were determined from semilogarithmic plots of CEA concentration time courses in 20 patients with recurrent gastric cancer and 17 with recurrent colorectal cancer.
Gastric and colorectal carcinomas showed mean CEA doubling times of 229 days and 85 days, respectively. There were no significant differences with regard to patient age, tumor size, gross appearance and histological differentiation. However, women had shorter CEA doubling times than did men. Flow cytometric analysis showed that tumors with a higher proportion of cells in S-phase (> or = 15%) had significantly shorter CEA doubling times than those with a lower S-phase fraction (< 15%). There was a significant correlation between the CEA doubling time and the length of survival after the initial CEA concentration increase in patients with recurrent gastric and colorectal carcinomas.
CEA doubling time predicts life expectancy in patients with adenocarcinoma of the gastrointestinal tract. Differences in survival time are closely associated with variations in the biological aggressiveness of individual tumors.
本研究旨在确定癌胚抗原（CEA）浓度倍增时间是否可预测胃肠道腺癌患者的疾病进程并表征肿瘤生物学特性。
通过对20例复发性胃癌患者和17例复发性结直肠癌患者的CEA浓度时间进程的半对数图来确定CEA倍增时间。
胃癌和结直肠癌的平均CEA倍增时间分别为229天和85天。在患者年龄、肿瘤大小、大体外观和组织学分化方面无显著差异。然而，女性的CEA倍增时间比男性短。流式细胞术分析显示，S期细胞比例较高（≥15%）的肿瘤的CEA倍增时间明显短于S期比例较低（<15%）的肿瘤。复发性胃癌和结直肠癌患者初始CEA浓度升高后的CEA倍增时间与生存长度之间存在显著相关性。
CEA倍增时间可预测胃肠道腺癌患者的预期寿命。生存时间的差异与个体肿瘤生物学侵袭性的变化密切相关。
