Henson K L, Alleman A R, Cutler T J, Ginn P E, Kelley L C
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0125, USA.
J Am Vet Med Assoc. 1998 May 1;212(9):1419-22.
A 9-year-old Arabian mare was admitted for evaluation of multiple subcutaneous nodules and infertility. Fine-needle aspiration of one of the subcutaneous nodules resulted in a cytologic diagnosis of histiolymphocytic lymphoma. Palpation per rectum and transrectal ultrasonography revealed a mass associated with the left ovary. Excision of the ovarian tumor was performed, and a histopathologic diagnosis of granulosa-theca cell tumor was made. After removal of the granulosa-theca cell tumor, subcutaneous nodules regressed. The referring veterinarian reported that the nodules had also disappeared and then recurred after administration of a synthetic progestin. To further characterize the lymphoma and investigate this possible hormonal relationship, immunophenotyping and estrogen and progesterone receptor assays were performed. The subcutaneous lymphoma was classified as a T-cell rich B-cell lymphoma, results of estrogen receptor assays were negative, and results of progesterone receptor assays were positive. Clinical observations of subcutaneous lymphoma in horses indicate that the waxing and waning nature of these tumors may be associated with the estrous cycle, pregnancy, foaling, and lactation. Clinical observations and identification of progesterone receptors suggest that a relationship between serum steroid hormone concentrations, such as estrogen and progesterone, and subcutaneous lymphoma may exists.
一匹9岁的阿拉伯母马因多个皮下结节和不孕症入院评估。对其中一个皮下结节进行细针穿刺，细胞学诊断为组织细胞淋巴细胞性淋巴瘤。直肠触诊和经直肠超声检查发现左侧卵巢有一个肿块。切除了卵巢肿瘤，组织病理学诊断为颗粒细胞瘤。切除颗粒细胞瘤后，皮下结节消退。转诊兽医报告称，在给予合成孕激素后，结节也消失了，然后又复发。为了进一步明确淋巴瘤的特征并研究这种可能的激素关系，进行了免疫表型分析以及雌激素和孕激素受体检测。皮下淋巴瘤被分类为富含T细胞的B细胞淋巴瘤，雌激素受体检测结果为阴性，孕激素受体检测结果为阳性。对马皮下淋巴瘤的临床观察表明，这些肿瘤的消长特性可能与发情周期、妊娠、产驹和泌乳有关。临床观察和孕激素受体的鉴定表明，血清类固醇激素浓度（如雌激素和孕激素）与皮下淋巴瘤之间可能存在关联。
