Zhao G, Li B
Department of Ophthalmology, Third Hospital, Beijing Medical University.
Zhonghua Yan Ke Za Zhi. 1996 May;32(3):167-75.
To investigate the free hard palate mucosal autograft as a new replacement in eyelid reconstruction.
(1) Animal experiment, 12 eyelid defects from 3 dogs were repaired with hard palate mucosal autograft, and after operation they had excellent eyelid appearance. The findings of pathological examination, the morphology and thickness of epithelium are the same as its original. The cells and vascularization in the connective tissue are normal. The arrangement of collagen fiber bundles is regular. (2) Clinical practice, 15 eyelid defects from 13 eyes included 3 upper eyelids, 8 lower eyelids and 2 of both upper and lower eyelids. 5 cases were of malignant tumor and 8 cases of trauma. 6 eyelids were of total defect, 4 eyelids of two-third defect and 5 eyelids of a half to one-third defect. The ages ranged from 22 to 79 years old. We used the intermediate split thickness of hard palate mucosal autograft to do the eyelid reconstruction. All the cases were followed for an average of 11.3 months after the reconstruction.
8 eyelid defects were cured, 3 were improved significantly and 4 improved. No severe complications were found.
The hard palate mucosal autograft acts not only as a palpebral supporting tissue but also forms palpebral conjunctiva.
探讨游离硬腭黏膜自体移植作为眼睑重建新替代物的效果。
(1)动物实验,用硬腭黏膜自体移植修复3只犬的12处眼睑缺损,术后眼睑外观良好。病理检查结果显示,上皮的形态和厚度与原来相同。结缔组织中的细胞和血管化正常。胶原纤维束排列规则。(2)临床实践,13只眼中的15处眼睑缺损包括3处上睑缺损、8处下睑缺损以及2处上下睑均有的缺损。5例为恶性肿瘤,8例为外伤。6处眼睑为全层缺损,4处眼睑为三分之二缺损,5处眼睑为二分之一至三分之一缺损。年龄范围为22至79岁。我们采用硬腭黏膜自体移植的中厚层进行眼睑重建。重建后所有病例平均随访11.3个月。
8处眼睑缺损治愈,3处明显改善,4处有所改善。未发现严重并发症。
硬腭黏膜自体移植不仅可作为眼睑支撑组织,还可形成睑结膜。