慢性粒细胞白血病：α干扰素治疗对循环中性粒细胞吞噬活性和能力的影响

Chronic myelogenous leukemia: effect of interferon-alpha treatment on phagocytic activity and capacity of circulating neutrophils.

作者信息

Kasimir-Bauer S, Ottinger H, Wuttke M, Stellberg W, Grosse-Wilde H, Seeber S, Scheulen M E

机构信息

Department of Internal Medicine (Cancer Research), University of Essen Medical School, Germany.

出版信息

Leuk Res. 1998 Feb;22(2):115-7. doi: 10.1016/s0145-2126(97)00185-9.

DOI:10.1016/s0145-2126(97)00185-9

PMID:9593467

Abstract

This study focuses on the effect of interferon (IFN)-alpha on phagocytosis of FITC-labeled Escherichia coli by polymorphonuclear neutrophils (PMNs) in chronic myelogenous leukemia (CML). The phagocytic activity and capacity of PMNs from IFN-alpha treated patients (n = 17), untreated CML patients (n = 9) and from healthy donors (n = 20) were compared using flow cytometry. Both parameters of PMN phagocytosis were reduced in untreated CML and in IFN-alpha treated CML with Ph1 chromosome persistence but normal in IFN-alpha treated CML with Ph1 conversion. Thus, the phagocytic performance of PMNs in patients with chronic phase CML is significantly improved after successful treatment with IFN-alpha.

摘要

本研究聚焦于α干扰素（IFN）对慢性粒细胞白血病（CML）患者多形核中性粒细胞（PMN）吞噬异硫氰酸荧光素（FITC）标记的大肠杆菌的影响。使用流式细胞术比较了来自接受α干扰素治疗的患者（n = 17）、未治疗的CML患者（n = 9）以及健康供体（n = 20）的PMN的吞噬活性和能力。未治疗的CML患者以及伴有Ph1染色体持续存在的接受α干扰素治疗的CML患者的PMN吞噬作用的两个参数均降低，但伴有Ph1染色体转化的接受α干扰素治疗的CML患者的PMN吞噬作用的两个参数正常。因此，慢性期CML患者经α干扰素成功治疗后，PMN的吞噬性能显著改善。