正常受试者血清中华法林与蛋白质结合的个体间差异。
Intersubject variation of warfarin binding to protein in serum of normal subjects.
作者信息
Yacobi A, Stoll R G, DiSanto A R, Levy G
出版信息
Res Commun Chem Pathol Pharmacol. 1976 Aug;14(4):743-6.
PMID:959669
Abstract
The protein binding of warfarin was determined in the serum of 18 normal adult subjects (8 males and 10 females). A statistically significant negative correlation between free fraction of warfarin and albumin concentration was found. The free fraction of warfarin in the serum of women was significantly larger than that in the serum of men, apparently due to the lower albumin concentration in the serum of women.
摘要
在18名正常成年受试者（8名男性和10名女性）的血清中测定了华法林的蛋白结合率。发现华法林的游离分数与白蛋白浓度之间存在统计学上显著的负相关。女性血清中华法林的游离分数明显高于男性血清中的游离分数，这显然是由于女性血清中白蛋白浓度较低所致。
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