[Screening and genetic analysis of fragile X syndrome in Tongling Anhui province of China].

OBJECTIVE

To investigate the prevalence of fragile X syndrome in the Chinese.

METHODS

Fragile X syndrome was screened from 172,600 people living in Tongling city, Anhui province. Suspected patients were tested by PCR and Southern Blotting.

RESULTS

Seven of 88 mental handicap children were found with fra (X), including 3 female and 4 male patients. Six patients, 3 normal transmitting males and 5 carriers were found in detailed search in these 6 fra (X) families. Genetic linkage analyses of 2 of the families were reported here.

CONCLUSION

The prevalence of fragile X syndrome in the Chinese is not apparently different from the previous reports on the Caucasian population.