[I型胶原相关物质作为前列腺癌骨转移标志物的研究，特别关注I型前胶原血清羧基末端前肽（PICP）、I型胶原交联羧基末端端肽（ICTP）及尿脱氧吡啶啉水平]

[Studies of type I collagen related substances as bone metastatic markers of prostate carcinoma with special regard to serum carboxyterminal propeptide of type. I. Procollagen (PICP), cross-linked carboxyterminal telopeptide of type I collagen (ICTP) and Urinary deoxypyridinoline levels].

作者信息

Imai T, Honda M, Maeda S, Hosoya Y, Arai T, Sumi S, Umeda H, Yano M, Koga F, Arai K, Yoshida K

机构信息

Department of Urology, Dokkyo University School of Medicine.

出版信息

Nihon Hinyokika Gakkai Zasshi. 1998 Apr;89(4):484-91. doi: 10.5980/jpnjurol1989.89.484.

DOI:10.5980/jpnjurol1989.89.484

PMID:9597867

Abstract

BACKGROUND

To investigate if serum levels of carboxyterminal propeptide of type I procollagen (PICP), cross-linked carboxyterminal telopeptide of type I collagen (ICTP) and urinary levels of deoxypyridinoline (D-Pyr) are useful markers of bone metastasis in patients with prostate carcinoma, we measured these markers in patients with untreated benign prostatic hyperplasia (BPH) and untreated prostate carcinoma (PCA).

METHODS

Serum PICP, ICTP and urinary D-Pyr levels were determined in 53 patients; 16 patients with BPH, 15 patients with PCA without bone metastasis (stage A, B, C and D1) and 22 patients with PCA with bone metastasis (stage D2). At the same time correlations among these markers and serum total alkaline phosphatase (ALP) activity were studied.

RESULTS

Serum PICP, ICTP and urinary D-Pyr levels in the PCA patients with bone metastasis were significantly higher than those of BPH. The serum levels of PICP in patients with PCA with bone metastasis group were significantly higher than those of without bone metastasis group. The serum levels of ICTP in patients with PCA without bone metastasis group were significantly higher than those of BPH group, while no significant difference was observed between PCA group with and without bone metastasis. In the PCA patients with bone metastasis, serum PICP and serum total alkaline phosphatase (ALP) activity were significantly correlated (r = 0.80). In these patients, serum ICTP and urinary D-Pyr levels were also significantly correlated (r = 0.70).

CONCLUSION

These results suggest that serum PIPC, ICTP and urinary D-Pyr are the useful markers to quantitate bone metastasis in the patients with PCA. Moreover, the determination of serum ICTP levels may be significant for detecting occult bone metastasis in the patients with PCA.

摘要

背景

为了研究血清I型前胶原羧基末端前肽（PICP）、I型胶原交联羧基末端肽（ICTP）水平以及尿脱氧吡啶啉（D-Pyr）水平是否为前列腺癌患者骨转移的有用标志物，我们对未经治疗的良性前列腺增生（BPH）患者和未经治疗的前列腺癌（PCA）患者进行了这些标志物的检测。

方法

测定了53例患者的血清PICP、ICTP和尿D-Pyr水平；其中16例BPH患者，15例无骨转移的PCA患者（A、B、C和D1期）以及22例有骨转移的PCA患者（D2期）。同时研究了这些标志物与血清总碱性磷酸酶（ALP）活性之间的相关性。

结果

有骨转移的PCA患者的血清PICP、ICTP和尿D-Pyr水平显著高于BPH患者。有骨转移的PCA患者组的血清PICP水平显著高于无骨转移组。无骨转移的PCA患者组的血清ICTP水平显著高于BPH组，而有骨转移和无骨转移的PCA组之间未观察到显著差异。在有骨转移的PCA患者中，血清PICP与血清总碱性磷酸酶（ALP）活性显著相关（r = 0.80）。在这些患者中，血清ICTP与尿D-Pyr水平也显著相关（r = 0.70）。