白血病发生：Myb基因的微小差异具有重大影响。
Leukemogenesis: small differences in Myb have large effects.
作者信息
Graf T
机构信息
EMBL, Heidelberg, Germany.
出版信息
Curr Biol. 1998 May 7;8(10):R353-5. doi: 10.1016/s0960-9822(98)70220-9.
PMID:9601636
Abstract
The avian retroviruses E26 and AMV carry mutated versions of the gene encoding the cellular transcription factor c-Myb. Surprisingly, these two mutant forms of Myb differ in the subsets of myeloid cells that they transform, the target genes that they activate, and the way in which they are regulated.
摘要
禽逆转录病毒E26和AMV携带编码细胞转录因子c-Myb的基因的突变版本。令人惊讶的是，这两种Myb突变形式在它们转化的髓系细胞亚群、它们激活的靶基因以及它们的调控方式上存在差异。
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