Sandinha T, Lee W R, Reid R
Department of Pathology, University of Glasgow, Western Infirmary, UK.
Graefes Arch Clin Exp Ophthalmol. 1998 May;236(5):333-8. doi: 10.1007/s004170050087.
This report describes the pathology of an unusual variant of fibroma of the eyelid. The soft ovoid tumour was excised from the centre of the left lower lid in an 84-year-old patient had been growing slowly for several years.
The tumour was studied by conventional histology, immunohistochemistry and electron microscopy.
The tumor was formed by fibroblasts of spindle and multinucleate type, and the collagenous stroma contained mast cells and blood vessels which exhibited minor inflammatory changes. With the immunohistochemical methods the only positive marker was for vimentin.
On morphological grounds it was possible to distinguish this extremely rare tumour from other mesenchymal tumours. The presence of distinctive multinucleate giant cells makes the term pleomorphic fibroma an appropriate name for this type of lesion.
本报告描述了一种眼睑纤维瘤不寻常变体的病理学特征。该柔软的卵形肿瘤是从一名84岁患者左下眼睑中央切除的,其已缓慢生长数年。
通过传统组织学、免疫组织化学和电子显微镜对肿瘤进行研究。
肿瘤由梭形和成多核型的成纤维细胞构成,胶原基质中含有肥大细胞和血管,呈现轻微炎症变化。免疫组织化学方法检测显示,唯一阳性标志物为波形蛋白。
基于形态学依据,可将这种极为罕见的肿瘤与其他间充质肿瘤区分开来。独特的多核巨细胞的存在使得“多形性纤维瘤”这一术语成为此类病变的合适名称。