结直肠癌肝转移患者内皮素-1水平升高。

Raised endothelin 1 levels in patients with colorectal liver metastases.

作者信息

Shankar A, Loizidou M, Aliev G, Fredericks S, Holt D, Boulos P B, Burnstock G, Taylor I

机构信息

Department of Surgery, University College Medical School, London, UK.

出版信息

Br J Surg. 1998 Apr;85(4):502-6. doi: 10.1046/j.1365-2168.1998.00660.x.

DOI:10.1046/j.1365-2168.1998.00660.x

PMID:9607532

Abstract

BACKGROUND

Endothelin 1 (ET-1), a vasoconstrictor peptide, has been implicated as a tumour growth stimulator and an angiogenesis factor.

METHODS

To assess the involvement of ET-1 in colorectal cancer, immunoelectron microscopy for ET-1 was performed in colorectal liver metastases and normal liver (n = 6). ET-1 plasma levels were measured by radioimmunoassay in patients with colorectal cancer, with (n = 18) and without (n = 12) liver metastases, and in controls (n = 22).

RESULTS

In normal liver, ET-1 was present in endothelial cells; in tumour, it was observed in endothelial cells, tumour cells and myofibroblasts. Mean(s.d.) plasma ET-1 levels were 2.75 (1.37) pg/ml in controls, 4.53(1.61) pg/ml in patients with colorectal liver metastases (P = 0.001) and 3.92(1.32) pg/ml in patients without metastases (P = 0.02).

CONCLUSION

ET-1 was present in various cell types within colorectal liver metastases and raised levels were found in the plasma of patients with colorectal cancer. ET-1 may not only modulate tumour vascular tone but also act on tumour growth and angiogenesis, both locally and systemically.

摘要

背景

内皮素1（ET-1）是一种血管收缩肽，被认为是肿瘤生长刺激因子和血管生成因子。

方法

为评估ET-1在结直肠癌中的作用，对结直肠癌肝转移灶和正常肝脏（n = 6）进行ET-1免疫电子显微镜检查。采用放射免疫分析法测定结直肠癌伴肝转移患者（n = 18）、不伴肝转移患者（n = 12）及对照组（n = 22）的血浆ET-1水平。

结果

在正常肝脏中，ET-1存在于内皮细胞中；在肿瘤中，在内皮细胞、肿瘤细胞和成肌纤维细胞中均观察到ET-1。对照组血浆ET-1平均（标准差）水平为2.75（1.37）pg/ml，结直肠癌肝转移患者为4.53（1.61）pg/ml（P = 0.001），无转移患者为3.92（1.32）pg/ml（P = 0.02）。