Martin R W, Perry K G, Martin J N, Seago D P, Roberts W E, Morrison J C
Division of Maternal-Fetal Medicine, University of Mississippi Medical Center Jackson, USA.
J Miss State Med Assoc. 1998 May;39(5):180-2.
Following parenteral magnesium tocolysis for patients in preterm labor. The choice of oral tocolytic medications is controversial.
Over a six-month period, 47 patients who were inpreterm labor were randomized after parenteral magnesium tocolysis to receive magnesium gluconate ([Mg-g] 648 mg elemental magnesium/day) or magnesium chloride ([Mg-c] 640 mg elemental magnesium/ day). A serum magnesium was obtained 24 hours after the initiation of oral therapy.
In the 25 patients were treated with Mg-g and 22 with Mg-c there were no differences in patient demographics, initial cervical dilatation hours on parenteral magnesium sulfate, recurrent contractions, or side effects between the two groups. The cost was also similar (Mg-c, $1.40/d; Mg-g, $2.11/d). The serum magnesium levels were higher in the Mg-c group (1.80 +/- 0.28 mg/dl) compared to the Mg-g group (1.63 +/- 0.30 mg/dl) but the difference was not significant.
These two preparations of magnesium are similar in their effects on uterine activity and serum levels when used at these dosages.
针对早产患者进行胃肠外镁剂抑制宫缩治疗后，口服宫缩抑制剂的选择存在争议。
在六个月的时间里，47例早产患者在接受胃肠外镁剂抑制宫缩治疗后被随机分组，分别接受葡萄糖酸镁（[Mg-g]，元素镁648毫克/天）或氯化镁（[Mg-c]，元素镁640毫克/天）治疗。口服治疗开始24小时后检测血清镁水平。
25例接受Mg-g治疗的患者和22例接受Mg-c治疗的患者在人口统计学特征、胃肠外硫酸镁治疗时的初始宫颈扩张程度、宫缩复发情况或两组间的副作用方面均无差异。费用也相似（Mg-c，1.40美元/天；Mg-g，2.11美元/天）。与Mg-g组（1.63±0.30毫克/分升）相比，Mg-c组的血清镁水平更高（1.80±0.28毫克/分升），但差异不显著。
这两种镁制剂在以这些剂量使用时，对子宫活动和血清水平的影响相似。
