口服镁用于保胎：葡萄糖酸镁与肠溶氯化镁的比较

Oral magnesium for tocolysis: a comparison of magnesium gluconate and enteric-coated magnesium chloride.

作者信息

Martin R W, Perry K G, Martin J N, Seago D P, Roberts W E, Morrison J C

机构信息

Division of Maternal-Fetal Medicine, University of Mississippi Medical Center Jackson, USA.

出版信息

J Miss State Med Assoc. 1998 May;39(5):180-2.

PMID:9610075

Abstract

PURPOSE

Following parenteral magnesium tocolysis for patients in preterm labor. The choice of oral tocolytic medications is controversial.

METHODS

Over a six-month period, 47 patients who were inpreterm labor were randomized after parenteral magnesium tocolysis to receive magnesium gluconate ([Mg-g] 648 mg elemental magnesium/day) or magnesium chloride ([Mg-c] 640 mg elemental magnesium/ day). A serum magnesium was obtained 24 hours after the initiation of oral therapy.

RESULTS

In the 25 patients were treated with Mg-g and 22 with Mg-c there were no differences in patient demographics, initial cervical dilatation hours on parenteral magnesium sulfate, recurrent contractions, or side effects between the two groups. The cost was also similar (Mg-c, $1.40/d; Mg-g, $2.11/d). The serum magnesium levels were higher in the Mg-c group (1.80 +/- 0.28 mg/dl) compared to the Mg-g group (1.63 +/- 0.30 mg/dl) but the difference was not significant.

CONCLUSION

These two preparations of magnesium are similar in their effects on uterine activity and serum levels when used at these dosages.

摘要

目的

针对早产患者进行胃肠外镁剂抑制宫缩治疗后，口服宫缩抑制剂的选择存在争议。

方法

在六个月的时间里，47例早产患者在接受胃肠外镁剂抑制宫缩治疗后被随机分组，分别接受葡萄糖酸镁（[Mg-g]，元素镁648毫克/天）或氯化镁（[Mg-c]，元素镁640毫克/天）治疗。口服治疗开始24小时后检测血清镁水平。

结果

25例接受Mg-g治疗的患者和22例接受Mg-c治疗的患者在人口统计学特征、胃肠外硫酸镁治疗时的初始宫颈扩张程度、宫缩复发情况或两组间的副作用方面均无差异。费用也相似（Mg-c，1.40美元/天；Mg-g，2.11美元/天）。与Mg-g组（1.63±0.30毫克/分升）相比，Mg-c组的血清镁水平更高（1.80±0.28毫克/分升），但差异不显著。