孤立性盆腔肿块女性患者的癌胚抗原。临床应用价值？

Carcinoembryonic antigen in women with isolated pelvic masses. Clinical utility?

作者信息

Roman L D, Muderspach L I, Burnett A F, Morrow C P

机构信息

Department of Obstetrics and Gynecology, Women's and Children's Hospital, Los Angeles, California, USA.

出版信息

J Reprod Med. 1998 May;43(5):403-7.

PMID:9610461

Abstract

OBJECTIVE

To determine the usefulness of serum carcinoembryonic antigen (CEA) determination in predicting the nature of an isolated pelvic mass.

STUDY DESIGN

Two hundred twenty-six women with an isolated pelvic mass had a serum CEA determination preoperatively. The results were correlated with the histopathologic findings.

RESULTS

CEA was elevated in 19 of the 226 women. Twelve of the 183 (7%) women with benign masses, 2 of the 17 (12%) women with tumors of low malignant potential and 5 of the 15 (33%) women with a frankly invasive epithelial ovarian cancer had elevated CEA. None of the women with a malignant germ cell or stromal tumor had elevated CEA (P = .06 for prediction of malignancy.) There were no cases of metastatic gastrointestinal malignancies in the study group. The sensitivity, specificity, positive predictive value and negative predictive value of serum CEA were 16%, 93%, 37% and 83%, respectively. The corresponding figures for serum CA-125 were 67%, 71%, 35% and 90%. There was no statistically significant correlation between elevated CEA and mucinous histology.

CONCLUSION

Preoperative serum CEA determination in women with isolated pelvic masses is not useful.

摘要

目的

确定血清癌胚抗原（CEA）测定在预测孤立性盆腔肿块性质方面的作用。

研究设计

226例患有孤立性盆腔肿块的女性患者在术前进行了血清CEA测定。结果与组织病理学检查结果相关。

结果

226例女性中有19例CEA升高。183例（7%）良性肿块女性中有12例，17例（12%）低恶性潜能肿瘤女性中有2例，15例（33%）侵袭性上皮性卵巢癌女性中有5例CEA升高。恶性生殖细胞或间质肿瘤女性中无一例CEA升高（预测恶性肿瘤的P = 0.06）。研究组中无转移性胃肠道恶性肿瘤病例。血清CEA的敏感性、特异性、阳性预测值和阴性预测值分别为16%、93%、37%和83%。血清CA - 125的相应数值分别为67%、71%、35%和90%。CEA升高与黏液性组织学之间无统计学显著相关性。