一种编码类似Env膜糖蛋白（gp55）并被嗜异性鼠白血病病毒Env gp70序列替代的突变型嗜脾灶形成病毒的致病性。
Pathogenicity of a mutant friend spleen focus-forming virus encoding an Env-like membrane glycoprotein (gp55) with substitution by a xenotropic murine leukemia virus Env gp70 sequence.
作者信息
Yugawa T, Amanuma H
机构信息
Gene Technology and Safety Laboratory, Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan.
出版信息
Microbiol Immunol. 1998;42(4):335-9. doi: 10.1111/j.1348-0421.1998.tb02292.x.
Friend spleen focus-forming virus (F-SFFV) is a replication-defective acutely leukemogenic mouse retrovirus and encodes an envelope protein (Env)-like membrane glycoprotein (gp55) in its defective env gene, which is responsible for the early stage of the viral leukemogenesis. Gp55 is a modified Env protein and contains a polytropic mink cell focus-inducing (MCF) murine leukemia virus (MuLV) Env gp70-derived sequence in its amino-terminal region. To evaluate the possibility that the presumed binding of gp55 to an MCF MuLV receptor protein has some role in leukemogenesis, we examined the biological activities of a mutant gp55 (XE gp55), which has a xenotropic MuLV Env gp70 amino-terminal region. XE gp55 displayed almost the same biological activities as the wild-type gp55, excluding the above possibility.
Friend脾集落形成病毒（F-SFFV）是一种复制缺陷型急性致白血病小鼠逆转录病毒，在其缺陷的env基因中编码一种包膜蛋白（Env）样膜糖蛋白（gp55），该蛋白负责病毒白血病发生的早期阶段。Gp55是一种修饰的Env蛋白，在其氨基末端区域含有一个多嗜性水貂细胞集落诱导（MCF）鼠白血病病毒（MuLV）Env gp70衍生序列。为了评估gp55与MCF MuLV受体蛋白的假定结合在白血病发生中是否起作用，我们检测了一种具有嗜异性MuLV Env gp70氨基末端区域的突变型gp55（XE gp55）的生物学活性。XE gp55表现出与野生型gp55几乎相同的生物学活性，排除了上述可能性。
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