使用氰基丙烯酸酯/碘油混合物对不可切除肝细胞癌进行肝动脉栓塞术。

Arterial hepatic embolization of unresectable hepatocellular carcinoma using a cyanoacrylate/lipiodol mixture.

作者信息

Berghammer P, Pfeffel F, Winkelbauer F, Wiltschke C, Schenk T, Lammer J, Müller C, Zielinski C

机构信息

Department of Internal Medicine I, University of Vienna Medical School, Austria.

出版信息

Cardiovasc Intervent Radiol. 1998 May-Jun;21(3):214-8. doi: 10.1007/s002709900247.

DOI:10.1007/s002709900247

PMID:9626437

Abstract

PURPOSE

A survival analysis in 16 patients with unresectable hepatocellular carcinoma (HCC) undergoing transcatheter arterial embolization (TAE) using a combination of lipiodol and N-butyl-2-cyanoacrylate (5:1) was performed in a retrospective study.

METHODS

A combination of lipiodol and N-butyl-2-cyanoacrylate (5:1) was used for TAE. All patients had disease compatible with Okuda stages I and II.

RESULTS

Twenty-four embolizations were done; five patients had more than one embolization. Median alpha-fetoprotein levels declined from 116 to 48.6 ng/ml. A median of 0.3 ml cyanoacrylate was administered per patient. Median survival was 8.5 months (range 2-49 months). After a median follow-up of 4 years, 12 patients have died (75%). Okuda stage I and II patients had a median survival time of 34.4 and 5.5 months respectively. Few side effects (19%) were seen.

CONCLUSION

We conclude that the TAE procedure used [lipiodol and N-butyl-2-cyanoacrylate (5:1)] is safe and produced only few side effects, thus constituting a valuable therapeutic option for patients with Okuda stage I and II HCC.

摘要

目的

在一项回顾性研究中，对16例无法切除的肝细胞癌（HCC）患者进行经导管动脉栓塞术（TAE），使用碘油和N-丁基-2-氰基丙烯酸酯（5:1）的组合进行生存分析。

方法

使用碘油和N-丁基-2-氰基丙烯酸酯（5:1）的组合进行TAE。所有患者的疾病均符合奥田分期I期和II期。

结果

共进行了24次栓塞；5例患者进行了不止一次栓塞。甲胎蛋白水平中位数从116降至48.6 ng/ml。每位患者使用的氰基丙烯酸酯中位数为0.3 ml。中位生存期为8.5个月（范围2-49个月）。中位随访4年后，12例患者死亡（75%）。奥田分期I期和II期患者的中位生存时间分别为34.4个月和5.5个月。观察到的副作用很少（19%）。