Hercberg S
Bull Mem Acad R Med Belg. 1997;152(10-11):379-85; discussion 385-7.
Many epidemiologic studies based on an observational approach indicate that a high dietary intake or high blood concentrations of some antioxidant micronutrients are associated with a reduced risk of cardiovascular diseases and cancer at several common sites. Inconsistent results of intervention trials suggest that low risk of pathologies may be related to multiple nutrients consumed, at nutritional doses, and in combination. This hypothesis was the rationale of the SU.VI.MAX. study, a randomized double-blind, placebo-controlled, primary-prevention trial designed to test the efficacy of a daily supplementation with antioxidant vitamins and minerals at nutritional doses in reducing the major health problems in industrialized countries, and especially the main causes of premature death (cancers and cardiovascular diseases).
许多基于观察性方法的流行病学研究表明，某些抗氧化微量营养素的高膳食摄入量或高血液浓度与降低多个常见部位的心血管疾病和癌症风险相关。干预试验结果不一致表明，低发病风险可能与以营养剂量摄入的多种营养素及其组合有关。这一假设是SU.VI.MAX.研究的理论基础，该研究是一项随机双盲、安慰剂对照的一级预防试验，旨在测试每日补充营养剂量的抗氧化维生素和矿物质在减少工业化国家主要健康问题，尤其是过早死亡的主要原因（癌症和心血管疾病）方面的疗效。
