Ingrams D R, Volk M S, Biesman B S, Pankratov M M, Shapshay S M
Department of Otolaryngology-Head and Neck Surgery, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA.
Laryngoscope. 1998 Jun;108(6):883-6. doi: 10.1097/00005537-199806000-00017.
This experimental study investigates the effect of mitomycin C (MMC) on sinus mucosal healing. MMC has an antiproliferative action on fibroblasts. It is used in glaucoma surgery to prevent restenosis of fistulas. Antrostomies were drilled in rabbit maxillary sinuses. One side was used as a control and the other treated with MMC at a concentration of 0.04, 0.4, or 1 mg/mL. Two animals from each group were sacrificed at 1, 2, 4, and 12 weeks. The antrostomies in the control and 0.04-mg/mL groups had closed by 1 week; in the 0.4-mg/mL group by 4 weeks, and in the 1.0-mg/mL group by 12 weeks. Ciliary function was initially impaired but normalized within 1 week. Both light and scanning electron microscopy showed no permanent damage to the cilia. These results suggest that MMC can be used to delay closure of antrostomies in sinus surgery.
本实验研究探讨丝裂霉素C（MMC）对鼻窦黏膜愈合的影响。MMC对成纤维细胞有抗增殖作用。它用于青光眼手术以防止瘘管再狭窄。在兔上颌窦钻造瘘口。一侧用作对照，另一侧用浓度为0.04、0.4或1mg/mL的MMC处理。每组两只动物在1、2、4和12周时处死。对照和0.04mg/mL组的造瘘口在1周时闭合；0.4mg/mL组在4周时闭合，1.0mg/mL组在12周时闭合。纤毛功能最初受损，但在1周内恢复正常。光学显微镜和扫描电子显微镜均显示纤毛无永久性损伤。这些结果表明，MMC可用于延迟鼻窦手术中造瘘口的闭合。
