Waites R, Selvadurai H R, Oliver I R, Hudson A
Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom.
Cell. 1998 May 29;93(5):779-89. doi: 10.1016/s0092-8674(00)81439-7.
The organs of a higher plant show two fundamental axes of asymmetry: proximodistal and dorsoventral. Dorsoventrality in leaves, bracts, and petal lobes of Antirrhinum majus requires activity of the PHANTASTICA (PHAN) gene. Conditional mutants revealed that PHAN is also required for earlier elaboration of the proximodistal axis. PHAN was isolated and shown to encode a MYB transcription factor homolog. PHAN mRNA is first detected in organ initials before primordium initiation. The structure and expression pattern of PHAN, together with its requirement in two key features of organ development, are consistent with a role in specifying lateral organ identity as distinct from that of the stem or meristem. PHAN also appears to maintain meristem activity in a non-cell-autonomous manner.
近远轴和背腹轴。金鱼草叶片、苞片和花瓣裂片的背腹性需要PHANTASTICA（PHAN）基因的活性。条件突变体表明，PHAN对于近远轴的早期形成也是必需的。PHAN已被分离出来，并显示其编码一个MYB转录因子同源物。PHAN mRNA在原基起始之前首先在器官原基中被检测到。PHAN的结构和表达模式，以及其在器官发育的两个关键特征中的需求，与在指定侧向器官身份（与茎或分生组织不同）中的作用一致。PHAN似乎还以非细胞自主的方式维持分生组织的活性。
