Chakova L, Karakhanian E, Dimitrov H, Lutakova E
Department of Paediatrics, Higher Medical Institute, Plovdiv, Bulgaria.
Folia Med (Plovdiv). 1998;40(1):80-3.
Description of the side effects of antiepileptic drugs is commonly encountered in paediatric practice. In view of this we investigated the structural and functional changes undergone by the thyroid glands of epileptic children during the course of a long-term antiepileptic treatment. The study included 22 children with epilepsy aged 3.5 to 15 years. The thyroid status was assessed using clinical, ultrasound, and radioimmunological examinations. Clinical signs of initial hyperplasia of the thyroid gland were observed in 3 children. Volume abnormalities of the thyroid gland were found in 4 (18.2%) of the children. Abnormalities in the thyroid hormones and thyrotropin serum concentration were found in 5 children. The ultrasound examination revealed slight structural changes, decreased colloid uptake, and strip-like sprouts in 63.6% of the cases. These changes were significantly more common in children undergoing anticonvulsant polytherapy (12 of 22 children). The most general mechanisms of influence of the antiepileptic drugs on the thyroid status are discussed.
在儿科临床实践中，经常会遇到抗癫痫药物副作用的描述。鉴于此，我们研究了癫痫儿童在长期抗癫痫治疗过程中甲状腺所经历的结构和功能变化。该研究纳入了22名年龄在3.5至15岁的癫痫儿童。通过临床、超声和放射免疫检查对甲状腺状况进行评估。3名儿童出现了甲状腺最初增生的临床体征。4名（18.2%）儿童发现甲状腺体积异常。5名儿童甲状腺激素和促甲状腺素血清浓度异常。超声检查显示63.6%的病例存在轻微结构变化、胶体摄取减少和条索状芽生。这些变化在接受联合抗惊厥治疗的儿童（22名儿童中的12名）中更为常见。讨论了抗癫痫药物影响甲状腺状况的最常见机制。
