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[与血清素相互作用期间神经节苷脂胶束的结构变化]

[Structural changes in ganglioside micelles during interaction with serotonin].

作者信息

Chupriianova N E, Iampol'skaia G P, Veĭnberg A Ia, Samokhvalov G I

出版信息

Biofizika. 1976 May-Jun;21(3):453-8.

PMID:963094
Abstract

Structure changes of ganglioside micelles in the process of serotonin bonding are considered. It was shown by viscosimetric and differential refraction studies that stretching of elliptical ganglioside micelles in the serotonin bonding process took place. The scope of micelles form changes depends on the pH value. An increase of the micelles summary negative charge at pH 9 increased the number of bonding centres and simultaneously caused deeper deformation of micelles due to the repulsion of the identically charged groups.

摘要

研究了血清素结合过程中神经节苷脂胶束的结构变化。粘度测定和差示折射研究表明,在血清素结合过程中椭圆形神经节苷脂胶束发生了伸展。胶束形态变化的范围取决于pH值。在pH 9时胶束总负电荷的增加增加了结合中心的数量,同时由于相同电荷基团的排斥导致胶束更深的变形。

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