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大鼠脊髓背角中谷氨酸受体的定位

Localization of glutamate receptors in dorsal horn of rat spinal cord.

作者信息

Yung K K

机构信息

Department of Biology, Hong Kong Baptist University, Kowloon Tong, China.

出版信息

Neuroreport. 1998 May 11;9(7):1639-44. doi: 10.1097/00001756-199805110-00069.

Abstract

Immunocytochemical localization of metabotropic glutamate receptors (mGluRs) and ionotropic glutamate receptors (NMDA-type: NMDAR1 and NMDAR2A-C; AMPA-type: GluR1-4) was performed on sections of rat dorsal horn. Immunoreactivity for mGluR1 alpha was detected in laminae I-III of the dorsal horn, whilst mGluR2/3 immunoreactivity was detected primarily in lamina III. Immunoreactivity for NMDAR1, GluR1, GluR2, GluR2/3, GluR4 and GluR5/6/7 was strongly localized in neuronal elements of laminae I-III. Immunoreactivity for NMDAR2B was localized in laminae I-III. No mGluR5, NMDAR2A and NMDAR2C immunoreactivity was detected. In addition, immunoreactivity for receptors was found to co-localize with immunoreactivity for glutamate in the dorsal horn. The present results indicate that glutamate receptors are differentially localized in neuronal elements of dorsal horn where receptor-neurotransmitter interaction takes place.

摘要

对大鼠背角切片进行了代谢型谷氨酸受体(mGluRs)和离子型谷氨酸受体(NMDA型:NMDAR1和NMDAR2A - C;AMPA型:GluR1 - 4)的免疫细胞化学定位。在背角的I - III层检测到mGluR1α的免疫反应性,而mGluR2/3免疫反应性主要在III层检测到。NMDAR1、GluR1、GluR2、GluR2/3、GluR4和GluR5/6/7的免疫反应性强烈定位于I - III层的神经元成分中。NMDAR2B的免疫反应性定位于I - III层。未检测到mGluR5、NMDAR2A和NMDAR2C的免疫反应性。此外,发现受体的免疫反应性与背角中谷氨酸的免疫反应性共定位。目前的结果表明,谷氨酸受体在背角的神经元成分中差异定位,在那里发生受体 - 神经递质相互作用。

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