日本患者中HLA I类和II类等位基因与肌炎的关联。

Association of HLA class I and class II alleles with myositis in Japanese patients.

作者信息

Furuya T, Hakoda M, Higami K, Ueda H, Tsuchiya N, Tokunaga K, Kamatani N, Kashiwazaki S

机构信息

Institute of Rheumatology, Tokyo Women's Medical College, Japan.

出版信息

J Rheumatol. 1998 Jun;25(6):1109-14.

PMID:9632072

Abstract

OBJECTIVE

To investigate the correlation of HLA class I and class II antigens and alleles with various forms of myositis in Japanese patients.

METHODS

Eighty-four Japanese patients with myositis [22 with polymyositis (PM), 46 with dermatomyositis (DM), 16 with myositis overlapping with other collagen vascular diseases] were typed serologically for HLA-A, B, C antigens. HLA-DRB1, DQA1, and DQB1 alleles were determined by polymerase chain reaction dependent DNA typing methods. Fifty-eight Japanese controls were typed serologically while HLA-DRB1, DQA1, and DQB1 allele typing was carried out in 175, 95, and 104 controls, respectively.

RESULTS

HLA-B7 was higher in patients than controls [20.2 vs 6.9% in controls: p=0.02, odds ratio (OR)=3.4]. The increase of HLA-B7 was largely dependent on the increase in overlap patients (37.5%; p=0.005, OR=8.1). HLA-A24 and B52 were significantly decreased in PM as compared to DM, while CW3 was significantly increased in PM versus DM. DRB108 alleles were significantly increased in patients (36.9 vs 20.5% in controls; p=0.004, OR=2.3), especially in PM and DM. DQA10501 and DQB1*0301 were significantly decreased in patients [4.8 vs 13.7% in controls; p=0.04, OR=0.32, and 8.3 vs 20.2% in controls; p=0.02, OR=0.36, respectively].

CONCLUSION

HLA-class I and class II alleles associated with Japanese patients with myositis may be different from those associated with Caucasian patients.

摘要

目的

研究日本患者中I类和II类人类白细胞抗原（HLA）及其等位基因与各种类型肌炎的相关性。

方法

对84例日本肌炎患者[22例多发性肌炎（PM）、46例皮肌炎（DM）、16例肌炎合并其他胶原血管病]进行HLA-A、B、C抗原的血清学分型。采用聚合酶链反应依赖的DNA分型方法测定HLA-DRB1、DQA1和DQB1等位基因。对58例日本对照者进行血清学分型，同时分别对175例、95例和104例对照者进行HLA-DRB1、DQA1和DQB1等位基因分型。

结果

患者中HLA-B7高于对照者[对照者为6.9%，患者为20.2%：p = 0.02，优势比（OR）= 3.4]。HLA-B7的增加很大程度上取决于重叠患者的增加（37.5%；p = 0.005，OR = 8.1）。与DM相比，PM中HLA-A24和B52显著降低，而与DM相比，PM中CW3显著升高。患者中DRB108等位基因显著增加（对照者为20.5%，患者为36.9%；p = 0.004，OR = 2.3），尤其是在PM和DM中。患者中DQA10501和DQB1*0301显著降低[对照者分别为13.7%和20.2%，患者分别为4.8%和8.3%；p = 0.04，OR = 0.32以及p = 0.02，OR = 0.36]。