[多囊卵巢综合征女性中生长激素和催乳素对左旋多巴的反应]
[Responses of growth hormone and prolactin to L-Dopa in women with polycystic ovarian syndrome].
作者信息
Wu X, Gu Q, Su Y
机构信息
Nanjing Jinling Hospital.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 1997 Aug;32(8):489-91.
OBJECTIVE
To evaluate the altered dopaminergic modulation of growth hormone (GH) and prolactin (PRL) in polycystic ovarian syndrome (PCOS).
METHODS
Responses of GH and PRL to L-Dopa (L-DA) (500 mg) were observed in two PCOS groups (LH/FSH > or = 3, Group I, n = 15, LH/FSH < 3, Group II, n = 15) and the control (n = 20).
RESULTS
Significantly lower GH (P < 0.01) and higher PRL levels (P < 0.05 in group I) in the basal state, and lower responses of GH and PRL to L-DA were found in two PCOS groups as compared with the control.
CONCLUSION
The altered basal levels and blunted L-DA evoked responses of GH and PRL suggest a relative decrease of the dopaminergic activity in PCOS patients.
目的
评估多囊卵巢综合征（PCOS）患者生长激素（GH）和催乳素（PRL）多巴胺能调节的改变。
方法
观察两组PCOS患者（LH/FSH≥3，I组，n = 15；LH/FSH＜3，II组，n = 15）及对照组（n = 20）的GH和PRL对左旋多巴（L-DA）（500mg）的反应。
结果
与对照组相比，两个PCOS组基础状态下GH水平显著降低（P＜0.01），I组PRL水平升高（P＜0.05），且GH和PRL对L-DA的反应降低。
结论
GH和PRL基础水平的改变以及L-DA诱发反应的减弱表明PCOS患者多巴胺能活性相对降低。
Zotero 插件