Lee C, Tummon I, Martin J, Nisker J, Power S, Tekpetey F
Department of Gynaecology and Reproductive Medicine, London Health Sciences Centre, Ontario, Canada.
Hum Reprod. 1998 May;13(5):1157-8. doi: 10.1093/humrep/13.5.1157.
Withholding gonadotrophin administration (coasting) may prevent severe ovarian hyperstimulation syndrome (OHSS). To ascertain the effectiveness of this protection a cohort of 252 consecutive in-vitro fertilization (IVF) or IVF with intracytoplasmic sperm injection (ICSI) cycles was studied. Twenty women with exaggerated response were treated with coasting. Despite coasting, four patients developed severe OHSS requiring hospitalization. Two of these four patients also required paracentesis. Multiple regression analysis in coasting cycles revealed severe OHSS was related to youth, number of oocytes retrieved and serum oestradiol prior to human chorionic gonadotrophin (HCG). Risk of developing severe OHSS was multifactorial and not necessarily prevented by withholding gonadotrophin.
停用促性腺激素（延缓）可能预防严重的卵巢过度刺激综合征（OHSS）。为确定这种预防措施的有效性，对连续252个体外受精（IVF）或卵胞浆内单精子注射（ICSI）周期的队列进行了研究。20例反应过度的女性接受了延缓治疗。尽管采取了延缓措施，仍有4例患者发生严重OHSS需要住院治疗。这4例患者中的2例还需要进行腹腔穿刺术。对延缓周期的多因素回归分析显示，严重OHSS与年轻、获卵数以及注射人绒毛膜促性腺激素（HCG）前的血清雌二醇有关。发生严重OHSS的风险是多因素的，停用促性腺激素不一定能预防。
