Schmid M H, Hary C, Marstaller B, Konz B, Wendtner C M
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Frauenlobstr. 9-11, D-80337 Munich, Germany.
Eur J Dermatol. 1998 Jan-Feb;8(1):45-7.
A 64-year-old woman with an 11-year history of systemic lupus erythematosus and amputation of her left lower leg as a consequence of arterial embolism, presented with two large, non-healing ulcers on her right shank. Pyoderma gangrenosum associated with secondary antiphospholipid syndrome was diagnosed based upon the typical clinical features and increased antibodies to cardiolipin. Although an aggressive therapy with corticosteroids and cyclosporine was started, her condition continued to worsen. She finally died as a result of sepsis. We discuss the difficulties in diagnosis and therapy of SLE combined with the antiphospholipid syndrome and pyoderma gangrenosum.
一名64岁女性，有11年系统性红斑狼疮病史，因动脉栓塞行左小腿截肢术，现右小腿有两个大的不愈合溃疡。根据典型临床特征及抗心磷脂抗体升高，诊断为继发抗磷脂综合征的坏疽性脓皮病。尽管开始使用皮质类固醇和环孢素进行积极治疗，但她的病情仍继续恶化。她最终因败血症死亡。我们讨论了系统性红斑狼疮合并抗磷脂综合征和坏疽性脓皮病的诊断和治疗难点。
