[采用单室模型，比较51Cr-乙二胺四乙酸与99m锝-二乙三胺五乙酸斜率清除率对肾小球滤过率的估算]
[Comparison of 51Cr-EDTA with 99m-Tc-DTPA slope clearance for estimation of glomerular filtration rate using the one compartment model].
作者信息
Chapot C, Seifert H, Samnick S, Kirsch C M
机构信息
Universitätskliniken des Saarlandes, Radiologische Klinik, Deutschland.
出版信息
Nuklearmedizin. 1998 Jun;37(4):124-8.
AIM
Of this study is to determine the relationship between 51Cr-EDTA and 99mTc-DTPA slope clearance applying the "one-compartment model".
METHODS
The "one-compartment model" was chosen to calculate and to compare the glomerular filtration rates of 25 patients with normal and pathological creatinin values after injection of 51Cr-EDTA and 99mTc-DTPA simultaneously.
RESULTS
The two clearance values correlated well (r = 0.996), and the 99mTc-DTPA clearance was systematically higher (28%). The 99mTc-DTPA was calculated and compared after taking three plasma samples. Taking two samples, only minor differences were seen and the correlation was high (r = 0.992).
CONCLUSION
The results of this study encouraged us to adopt the use of 99mTc-DTPA instead of 51Cr-EDTA in determining the glomerular filtration applying the "one-compartment model" in slope with two plasma samples.
目的
本研究旨在应用“单室模型”确定51Cr - EDTA与99mTc - DTPA斜率清除率之间的关系。
方法
选择“单室模型”，在25例肌酐值正常和异常的患者同时注射51Cr - EDTA和99mTc - DTPA后，计算并比较其肾小球滤过率。
结果
两种清除率值相关性良好（r = 0.996），且99mTc - DTPA清除率系统性地更高（28%）。采集三份血浆样本后计算并比较99mTc - DTPA。采集两份样本时，仅观察到微小差异，且相关性较高（r = 0.992）。
结论
本研究结果促使我们在应用“单室模型”通过两份血浆样本斜率法测定肾小球滤过时采用99mTc - DTPA而非51Cr - EDTA。
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