Occurrence rates of HLA-DRB1, HLA-DQB1, and HLA-DPB1 alleles in patients suffering from vitiligo.

By investigating a group of 39 unrelated adults suffering from vitiligo it was found that alleles HLA-DRB10701, -DQB10201, and -DPB11601 differed in their frequencies in comparison to those observed in the healthy population. The allele HLA-DRB10701 was found in 26.5% of patients compared to 14.2% in the healthy group (p < 0,01, RR = 2.17). The allele HLA-DQB10201 was present in 33.8% of patients compared to 21.2% (p < 0,025, RR = 1.89). The allele HLA-DPB11601 was found in 6.41% of patients compared to 2.05% in the healthy group (p < 0.05, RR = 3.3). No other significant deviations in the frequencies of investigated alleles were observed.