Hasler C R, Reinhart W H
Internal Medicine, Kantonsspital, Chur, Switzerland.
Clin Hemorheol Microcirc. 1998 Apr;18(1):43-6.
Furosemide is a diuretic agent which is often given in high concentration intravenously. Since erythrocytes have a furosemide-sensitive transport system and oral application of furosemide was found to induce an echinocytic shape transformation in horses, we have analysed the influence of furosemide on erythrocyte shape, volume and blood viscosity in vitro. Increasing plasma furosemide concentrations of 0, 1, 10, 100 and 1000 micrograms/ml did not affect the erythrocyte volume or shape and left blood viscosity unaffected. We conclude that furosemide has no influence on blood rheology in humans.
速尿是一种利尿剂，常以高浓度静脉注射给药。由于红细胞具有对速尿敏感的转运系统，且发现口服速尿会导致马的红细胞呈棘形转变，因此我们在体外分析了速尿对红细胞形状、体积和血液粘度的影响。血浆速尿浓度分别为0、1、10、100和1000微克/毫升时，增加这些浓度并未影响红细胞体积或形状，也未改变血液粘度。我们得出结论，速尿对人类血液流变学没有影响。
