Weir M L, Klip A, Trimble W S
Program in Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
Biochem J. 1998 Jul 15;333 ( Pt 2)(Pt 2):247-51. doi: 10.1042/bj3330247.
We report the identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein (hVAP-33) that has been implicated in neuronal exocytosis in Aplysia californica. This hVAP-33 shared 50% amino acid identity with the A. californica form and had similar length, structural organization and VAMP-binding abilities. However, in contrast with the neuron-specific expression seen in A. californica, hVAP-33 was broadly expressed, suggesting possible roles in vesicle fusion in both neuronal and non-neuronal cells.
我们报告了一种与囊泡相关膜蛋白(VAMP)相关蛋白(hVAP-33)的人类同源物的鉴定,该蛋白与加州海兔的神经元胞吐作用有关。这种hVAP-33与加州海兔的形式具有50%的氨基酸同一性,并且具有相似的长度、结构组织和VAMP结合能力。然而,与在加州海兔中看到的神经元特异性表达不同,hVAP-33广泛表达,这表明它可能在神经元和非神经元细胞的囊泡融合中发挥作用。